Sauter A, Machura K, Neubauer B, Kurtz A, Wagner C
Institut für Physiologie der Universität Regensburg, D-93040 Regensburg, Germany.
Kidney Int. 2008 Jan;73(1):43-51. doi: 10.1038/sj.ki.5002571. Epub 2007 Sep 26.
During metanephric kidney development, renin is expressed in the walls of larger intrarenal arteries, but is restricted to the terminal part of the preglomerular arterioles in the adult kidney. Our study describes the three-dimensional development of renin expression in mouse kidneys during fetal and postnatal life. Renin immunoreactivity first appeared at day 14 of development in the cells expressing alpha-smooth muscle actin (alphaSMA) in the arcuate arteries. Before adulthood, the branching of the arcuate arterial tree increased exponentially and renin expression shifted from proximal to distal parts of the tree. Renin expression at branching points or in the cones of growing vessels was not seen. Instead, renin expression appeared after vessel walls and branches were already established, disappeared a few days later, and remained only in the juxtaglomerular regions of afferent arterioles. In these arterioles, coexpression of renin and alphaSMA disappeared gradually, with the terminal cells expressing only renin. At all stages of kidney development, renin expression among comparable vessel segments was heterogeneous. Renin expression remained stable after it reached the terminal parts of afferent arterioles.
在后肾发育过程中，肾素表达于较大的肾内动脉壁，但在成年肾脏中局限于入球小动脉的终末部分。我们的研究描述了小鼠肾脏在胎儿期和出生后肾素表达的三维发育过程。肾素免疫反应性最早在发育第14天出现在弓状动脉中表达α平滑肌肌动蛋白（αSMA）的细胞中。在成年之前，弓状动脉树的分支呈指数级增加，肾素表达从树的近端转移到远端。在分支点或生长血管的圆锥中未见肾素表达。相反，肾素表达在血管壁和分支已经形成后出现，几天后消失，仅保留在入球小动脉的球旁区域。在这些小动脉中，肾素和αSMA的共表达逐渐消失，终末细胞仅表达肾素。在肾脏发育的所有阶段，可比血管段之间的肾素表达是异质性的。肾素表达到达入球小动脉的终末部分后保持稳定。
