Li Changdong, Zhang Weiyuan, Jiang Xiaoxia, Mao Ning
Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Yaojiayuan Road 251, Beijing 100026, People's Republic of China.
Cell Tissue Res. 2007 Dec;330(3):437-46. doi: 10.1007/s00441-007-0504-5. Epub 2007 Sep 25.
Evidence has emerged that mesenchymal stem cells (MSCs) represent a promising cell population for supporting new clinical cellular therapies. Currently, bone marrow represents the main source of MSCs, but their differentiation capacity declines with age. We have identified possible novel multilineage mesenchymal cells from human placenta. In addition to their multilineage differentiation, they have a direct immunosuppressive effect on proliferation of T lymphocytes from human adult peripheral blood (PB) and umbilical cord blood (UCB) in vitro. This immunoregulatory feature strongly implies that they have a potential application in allograft transplantation. Since placenta and UCB can be obtained from the same donor, placenta is an attractive source of MSCs for co-transplantation in conjunction with UCB-derived hematopoietic stem cells to reduce the potential of graft-versus-host disease in recipients. However, the way that they modulate the immune system is unclear. In this investigation, we have addressed the effects of human placental MSCs on various subtypes of UCB-derived and PB-derived T lymphocytes.
有证据表明，间充质干细胞（MSCs）是支持新型临床细胞疗法的有前景的细胞群体。目前，骨髓是MSCs的主要来源，但其分化能力会随着年龄的增长而下降。我们已经从人胎盘中鉴定出可能的新型多谱系间充质细胞。除了具有多谱系分化能力外，它们在体外对来自成人外周血（PB）和脐带血（UCB）的T淋巴细胞增殖具有直接的免疫抑制作用。这种免疫调节特性强烈表明它们在同种异体移植中具有潜在应用价值。由于胎盘和脐带血可以从同一供体获得，胎盘是一种有吸引力的MSCs来源，可与脐带血来源的造血干细胞联合进行共移植，以降低受体发生移植物抗宿主病的可能性。然而，它们调节免疫系统的方式尚不清楚。在本研究中，我们探讨了人胎盘间充质干细胞对脐带血来源和外周血来源的各种T淋巴细胞亚群的影响。
