Celentano Claudio, Prefumo Federico, di Vera Elena, Iannicco Annamaria, Gallo Davide Pio, Liberati Marco
Department of Obstetrics and Gynecology, University of Chieti, Via Sandro Pertini, 4, 65129, Pescara, Italy.
Pediatr Nephrol. 2008 Feb;23(2):333-4. doi: 10.1007/s00467-007-0618-8. Epub 2007 Sep 26.
We report on a case of fetal toxicity due to maternal treatment with olmesartan medoxomil. At 29 weeks' gestation, oligohydramnios was found, although the fetus had normal kidneys on ultrasound evaluation. Withdrawal of olmesartan medoxomil, maternal rehydration, and a single dose of furosemide reversed the renal impairment. After term delivery, the neonate was confirmed to have normal renal function. The case suggested that fetal renal impairment due to olmesartan medoxomil may be reversible.
我们报告了一例因母亲使用奥美沙坦酯治疗导致胎儿中毒的病例。妊娠29周时，发现羊水过少，尽管超声评估显示胎儿肾脏正常。停用奥美沙坦酯、母亲补液并单次给予呋塞米后，肾功能损害得到逆转。足月分娩后，新生儿肾功能被证实正常。该病例提示，奥美沙坦酯所致胎儿肾功能损害可能是可逆的。
