Saji H, Yamanaka M, Hagiwara A, Ijiri R
Lancet. 2001 Feb 3;357(9253):363. doi: 10.1016/S0140-6736(00)03648-5.
We report a case of maternal exposure to the antihypertensive drug losartan during weeks 20-31 of pregnancy. We saw the fetal toxic effects of oligohydramnios (decreased amniotic fluid), fetal pulmonary hypoplasia, fetal hypoplastic skull bones, and subsequent fetal death. This pattern of abnormalities is similar to those seen in exposure to angiotensin-converting-enzyme (ACE) inhibitors during pregnancy, and were probably caused by losartan.
我们报告了一例孕妇在妊娠20至31周期间接触抗高血压药物氯沙坦的病例。我们观察到羊水过少（羊水减少）、胎儿肺发育不全、胎儿颅骨发育不全以及随后的胎儿死亡等胎儿毒性作用。这种异常模式与孕期接触血管紧张素转换酶（ACE）抑制剂时所见的情况相似，可能是由氯沙坦引起的。
