与胚胎停育流产相比，空孕囊妊娠的细胞遗传学检测
Cytogenetic testing of anembryonic pregnancies compared to embryonic missed abortions.
作者信息
Lathi Ruth B, Mark Sara D, Westphal Lynn M, Milki Amin A
机构信息
Stanford University Medical Center, 300 Pasteur Drive HH333, Stanford, CA 94306, USA.
出版信息
J Assist Reprod Genet. 2007 Nov;24(11):521-4. doi: 10.1007/s10815-007-9166-1. Epub 2007 Sep 27.
Abstract
PURPOSE
The objective of this study is to determine the rate of abnormalities detected by cytogenetic testing of first trimester miscarriages, in patients with and without an embryonic pole seen on ultrasound.
MATERIALS AND METHODS
A retrospective study of 272 D&Cs for missed abortions in an academic infertility practice from 1999 to 2006. Karyotype results were compared with transvaginal ultrasound findings. Chi-squared analysis was used with a P < 0.05 for significance.
RESULTS
There was a high rate of abnormal karyotypes in all miscarriages (65%). Rates of abnormal karyotypes were 58% and 68% in cases with anembryonic gestations and those with a fetal pole seen, respectively (P > 0.05).
CONCLUSION
The high rate of abnormalities detected in both groups suggests that useful results can be obtained from chromosomal testing of the POC regardless of ultrasound findings. Further studies on the prognostic value and cost effectiveness of chromosomal testing are needed.
摘要
目的
本研究的目的是确定在超声检查中有无胎芽的孕早期流产患者，通过细胞遗传学检测发现的异常率。
材料与方法
对1999年至2006年在一家学术性不孕不育诊所进行的272例稽留流产刮宫术进行回顾性研究。将核型结果与经阴道超声检查结果进行比较。采用卡方分析，P < 0.05为有统计学意义。
结果
所有流产病例的核型异常率都很高（65%）。无胎芽妊娠病例和有胎芽可见病例的核型异常率分别为58%和68%（P > 0.05）。
结论
两组中检测到的高异常率表明，无论超声检查结果如何，从妊娠产物的染色体检测中都能获得有用的结果。需要进一步研究染色体检测的预后价值和成本效益。
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