Nezhinskaia G I, Losev N A, Sapronov N S
Patol Fiziol Eksp Ter. 2007 Apr-Jun(2):12-3.
Effects of methacine, hexamethonium and their combinations with neostigmine on activity of B-lymphocytes in various phases of immune response and development of stress ulcers induced in animals were studied. The drugs were found to modulate B-lymphocyte activity for 28 days and longer. By a water-immersion stress model it was shown that methacin is effective not only as m-cholinolytic but also as an immunoprophylactic drug reducing destructive changes in gastric mucosa. Injection of methacin 30 min before stress (block of m-cholinoreceptors) or 14 days before stress (maximal increase of B cell activity) results in 3-4-fold inhibition of ulcerogenesis in gastric mucosa.
研究了甲灭酸、六甲铵及其与新斯的明的组合对动物免疫反应各阶段B淋巴细胞活性以及应激性溃疡发生发展的影响。发现这些药物可调节B淋巴细胞活性达28天及更长时间。通过水浸应激模型表明，甲灭酸不仅作为M胆碱能阻滞剂有效，而且作为一种免疫预防药物可减少胃黏膜的破坏性变化。在应激前30分钟注射甲灭酸（阻断M胆碱受体）或在应激前14天注射（B细胞活性最大增加）可使胃黏膜溃疡形成受到3至4倍的抑制。
