Shamova O V, Lesnikova M P, Kokriakov V N, Shkhinek E K, Korneva E A
Biull Eksp Biol Med. 1993 Jun;115(6):646-9.
The influence of defensins on the level of corticosterone in the blood and immune response in stress was studied. Defensins were shown to have corticostatic activity in vivo in the models of stress- and ACTG-induced elevation of corticosterone. Also defensins abolished the immunosuppressive action of combining stress in animals. These results suggest that defensins may be endogenic peptides with stress-protective properties.
研究了防御素对血液中皮质酮水平以及应激状态下免疫反应的影响。在应激和促肾上腺皮质激素诱导的皮质酮升高模型中，防御素在体内表现出皮质酮抑制活性。此外，防御素消除了动物复合应激的免疫抑制作用。这些结果表明，防御素可能是具有应激保护特性的内源性肽。
