聚（3-（3-吡啶基）丙烯酸）修饰玻碳电极用于同时测定多巴胺、抗坏血酸和尿酸。
Poly (3-(3-pyridyl) acrylic acid) modified glassy carbon electrode for simultaneous determination of dopamine, ascorbic acid and uric acid.
作者信息
Zhang Yuzhong, Su Shao, Pan Yan, Zhang Liping, Cai Yuejuan
机构信息
College of Chemistry and Materials Science, Anhui Key Laboratory of Functional Molecular Solids, Anhui Normal University, Wuhu 241000, P.R. China.
出版信息
Ann Chim. 2007 Aug;97(8):665-74. doi: 10.1002/adic.200790051.
Trans-3-(3-pyridyl) acrylic acid (PAA) was deposited on glassy carbon electrode (GCE) by electropolymerization in pH 7.0 phosphate buffer solution (PBS). The poly (3-(3-pyridyl) acrylic acid) (PPAA) film modified glassy carbon electrode shows an excellent electrochemical response for dopamine (DA), ascorbic acid (AA) and uric acid (UA). The cyclic voltammetry oxidation peaks for DA and AA, DA and UA, AA and UA are separated by 150 mV, 130 mV and 280 mV, respectively. This permits the simultaneous determination of AA, DA and UA. The interference of AA with the determination of DA could be eliminated because of the electrostatic interaction between DA cations and the negatively charged PPAA film at pH 7.0. The anodic peak currents of DA, AA and UA increase linearly with concentration in the range of 1-40 micromol L(-1), 10-400 micromol L(-1) and 1.6-80 micromol L(-1), respectively, with a correlation coefficient (r) always higher than 0.998. The detection limit is 0.06 micromol L(-1), 0.8 micromol L(-1) and 1.1 micromol L(-1) for DA, AA and UA, respectively.
反式-3-(3-吡啶基)丙烯酸（PAA）在pH 7.0的磷酸盐缓冲溶液（PBS）中通过电聚合沉积在玻碳电极（GCE）上。聚（3-(3-吡啶基)丙烯酸）（PPAA）膜修饰的玻碳电极对多巴胺（DA）、抗坏血酸（AA）和尿酸（UA）表现出优异的电化学响应。DA与AA、DA与UA、AA与UA的循环伏安氧化峰分别相隔150 mV、130 mV和280 mV。这使得能够同时测定AA·、DA和UA。由于在pH 7.0时DA阳离子与带负电荷的PPAA膜之间的静电相互作用，AA对DA测定的干扰可以消除。DA、AA和UA的阳极峰电流分别在1 - 40 μmol L⁻¹、10 - 400 μmol L⁻¹和1.6 - 80 μmol L⁻¹范围内随浓度呈线性增加，相关系数（r）始终高于0.998。DA、AA和UA的检测限分别为0.06 μmol L⁻¹、0.8 μmol L⁻¹和1.1 μmol L⁻¹。
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