Fitscha P, Rauscha F, Rogatti W, Peskar B A, O'Grady J, Sinzinger H
2nd Department of Internal Medicine, Policlinic Vienna, Austria.
Eicosanoids. 1991;4(4):231-3.
PGE1 has antimitotic activity by virtue of its effect in increasing cAMP in vascular smooth muscle cells. The present study compares the effect of 13,14-dihydro-PGE1 (13,14-DH-PGE1) with PGE1 in an experimental model of stress induced by desoxycorticosterone in the rabbit. 13,14-DH-PGE1 significantly inhibited the stress-induced increase in mitotic activity, measured by autoradiography as percentage of 3H-thymidine positive cells, in all 3 abdominal aortic wall layers. Administration prior to stress was more effective than after stress, while combined administration was most effective. 13,14-DH-PGE1 exerts approximately 90% of the antimitotic activity of PGE1. It seems possible that the antimitotic activity observed after administration of intravenous PGE1 is attributable in part to 13,14-DH-PGE1.
前列腺素E1（PGE1）通过增加血管平滑肌细胞中环磷酸腺苷（cAMP）的水平而具有抗有丝分裂活性。本研究在兔脱氧皮质酮诱导的应激实验模型中比较了13,14-二氢前列腺素E1（13,14-DH-PGE1）与PGE1的作用。13,14-DH-PGE1显著抑制了应激诱导的有丝分裂活性增加，通过放射自显影术测量为3H-胸腺嘧啶核苷阳性细胞的百分比，在所有三层腹主动脉壁中均如此。应激前给药比应激后给药更有效，而联合给药最有效。13,14-DH-PGE1发挥了PGE1约90%的抗有丝分裂活性。静脉注射PGE1后观察到的抗有丝分裂活性似乎部分归因于13,14-DH-PGE1。
