Johannesson Ulrika, Sahlin Lena, Masironi Britt, Rylander Eva, Bohm-Starke Nina
Division of Obstetrics and Gynecology, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm 18288, Sweden.
Contraception. 2007 Oct;76(4):319-25. doi: 10.1016/j.contraception.2007.06.014. Epub 2007 Aug 28.
The objective was to evaluate the influence of combined oral contraceptives (COC) and of the menstrual cycle on the steroid receptor expression in the vulvar vestibular mucosa of healthy women.
Forty-five healthy women (20 with COC and 25 without) were included. Vestibular biopsies were obtained during the menstrual cycle. Estrogen receptors (ER) alpha and beta, progesterone receptors (PR) A and B, glucocorticoid receptor and androgen receptor as well as the proliferation marker Ki67 were analyzed using immunohistochemistry followed by computerized image analysis.
The vestibular stromal tissue of women using COC expressed more ERbeta (p=.024) than that of women without COC. In the follicular phase, PRB was more abundant in the stromal tissue than in the luteal phase (p=.01).
ERbeta is more abundant in the vulvar vestibular mucosa of women using COC than in that of women without COC. There is a cyclic variation in PRB in the vestibular mucosa in healthy women without COC.
目的是评估复方口服避孕药（COC）和月经周期对健康女性外阴前庭黏膜中类固醇受体表达的影响。
纳入45名健康女性（20名使用COC，25名未使用）。在月经周期期间获取前庭活检组织。使用免疫组织化学结合计算机图像分析，分析雌激素受体（ER）α和β、孕激素受体（PR）A和B、糖皮质激素受体和雄激素受体以及增殖标志物Ki67。
使用COC的女性的前庭间质组织比未使用COC的女性表达更多的ERβ（p = 0.024）。在卵泡期，间质组织中的PRB比黄体期更丰富（p = 0.01）。
使用COC的女性外阴前庭黏膜中的ERβ比未使用COC的女性更丰富。在未使用COC的健康女性中，前庭黏膜中的PRB存在周期性变化。
