Johannesson Ulrika, Sahlin Lena, Masironi Britt, Hilliges Marita, Blomgren Bo, Rylander Eva, Bohm-Starke Nina
Division of Obstetrics and Gynecology, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden.
Am J Obstet Gynecol. 2008 Mar;198(3):311.e1-6. doi: 10.1016/j.ajog.2007.09.041. Epub 2008 Feb 21.
This study was undertaken to survey the steroid receptor expression and morphology in the vulvar vestibular mucosa in women with provoked vestibulodynia.
Fourteen patients and 25 controls without oral contraceptives were included. Vestibular biopsy specimens were obtained and analyzed by using immunohistochemistry, followed by computerized image analysis of estrogen receptors alpha and beta, progesterone receptors A and B, glucocorticoid receptor, androgen receptor, and the proliferation marker Ki67. The morphology was estimated by measuring 4 parameters in the epithelium.
There was a significantly higher expression of estrogen receptor alpha in both the epithelium (P = .04) and the stroma (P = .02) in the patient specimens compared with the controls. There were no significant differences in the other analyses performed.
There is an increased expression of estrogen receptor alpha in the vestibular mucosa but the epithelial morphology seems unaffected in women with provoked vestibulodynia. Further studies regarding plausible associations to neurogenic inflammation are needed.
本研究旨在调查激发性前庭痛女性患者外阴前庭黏膜中类固醇受体的表达及形态。
纳入14例患者及25例未服用口服避孕药的对照者。获取前庭活检标本，采用免疫组织化学法进行分析，随后对雌激素受体α和β、孕激素受体A和B、糖皮质激素受体、雄激素受体以及增殖标志物Ki67进行计算机图像分析。通过测量上皮中的4个参数评估形态。
与对照组相比，患者标本的上皮（P = .04）和基质（P = .02）中雌激素受体α的表达均显著更高。其他分析未发现显著差异。
激发性前庭痛女性患者的前庭黏膜中雌激素受体α表达增加，但上皮形态似乎未受影响。需要进一步研究其与神经源性炎症的可能关联。
