用于标记RNA聚腺苷酸尾的含芘荧光探针的设计
Design of a pyrene-containing fluorescence probe for labeling of RNA poly(A) tracts.
作者信息
Tanaka Kazuo, Okamoto Akimitsu
机构信息
Frontier Research System, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama 351-0198, Japan.
出版信息
Bioorg Med Chem. 2008 Jan 1;16(1):400-4. doi: 10.1016/j.bmc.2007.09.024. Epub 2007 Sep 18.
PMID:17900910
Abstract
A labeling probe containing a pyrenecarboxamide-tethered modified DNA base, (Py)U, has been developed for fluorometric detection of RNA poly(A) tracts, in which the fluorescence emission intensity was controlled by the microstructural change around (Py)U caused by binding with the target RNA.
摘要
一种含有芘甲酰胺连接的修饰DNA碱基（Py）U的标记探针已被开发用于荧光检测RNA的聚腺苷酸序列，其中荧光发射强度由与靶RNA结合引起的（Py）U周围微观结构变化控制。
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