Barone D, Coccia G, Marziano C, Tricerri R
Servizio di Radioterapia, Ospedali Galliera, Genova.
Minerva Gastroenterol Dietol. 1991 Jul-Sep;37(3):187-93.
The prognosis of esophageal adenocarcinoma is extremely poor. Despite recent improvements in diagnostic and therapeutic techniques, the 5-years survival rate remains below 10%. Management is primarily surgical or radiotherapeutical, although pre- or postoperative radiation or chemotherapy are often employed. Chemotherapy alone, however, has not demonstrated great therapeutic efficacy in the management of this neoplasm. As most patients with cancer of the lower esophagus have an advanced stage of the disease and a very poor prognosis, the main aim of treatment should be to improve the quality of life. Intracavitary radiation (high dose rate) is a well recognised method of treatment alone or in combination with external radiotherapy. Its simplicity, the convenience of short treatment time and radiation safety provided by the remote after loading system make this the ideal palliative treatment in esophageal cancer. Endoscopic techniques, like dilation and endoprosthesis placement, laser therapy or BI-CAP probe, provide good palliation for dysphagia, with a low morbidity rate. The paper describes a case of lower esophageal adenocarcinoma treated with combined external and intracavitary radiation and endoscopic palliative techniques. Good control of the disease was achieved and the patient is alive 26 months after treatment with a good quality of life.
食管腺癌的预后极差。尽管近期诊断和治疗技术有所改进,但5年生存率仍低于10%。治疗主要采用手术或放射治疗,不过术前或术后放疗或化疗也经常使用。然而,单纯化疗在这种肿瘤的治疗中尚未显示出显著的疗效。由于大多数下段食管癌患者疾病已处于晚期且预后很差,治疗的主要目标应是提高生活质量。腔内放疗(高剂量率)是一种公认的单独治疗或与外照射放疗联合使用的方法。其操作简单、治疗时间短且远程后装系统提供的放射安全性使其成为食管癌理想的姑息治疗方法。内镜技术,如扩张和内置假体置入、激光治疗或BI-CAP探头,可为吞咽困难提供良好的姑息治疗,且发病率低。本文描述了一例采用外照射和腔内放疗及内镜姑息技术联合治疗的下段食管腺癌病例。疾病得到了良好控制,患者在治疗26个月后仍存活,生活质量良好。