Kinsella J P, Gerstmann D R, Gong A K, Taylor A F, deLemos R A
Department of Pediatrics, Fitzsimons Army Medical Center, Aurora, Col.
Biol Neonate. 1991;60(5):283-91. doi: 10.1159/000243419.
We studied the hemodynamic effects of using natural surfactant in premature baboons with hyaline membrane disease (HMD). Study animals (n = 5) received a single dose of surfactant immediately after delivery and control animals (n = 8) did not. Using microspheres at 3, 8, and 23 h we found no significant differences in left ventricular output, effective systemic flow, systemic-to-pulmonary patent ductus arteriosus (PDA) shunting, or in cerebral or renal organ blood flow. However, both groups had large PDA shunts (fraction of LVO to lungs greater than 0.40-0.55 at 3 and 8 h) resulting in low systemic perfusion (less than 80 ml/min/kg). Single dose surfactant did not improve the myocardial dysfunction and low cerebral and renal blood flow which occur during treatment for HMD.
我们研究了在患有透明膜病（HMD）的早产狒狒中使用天然表面活性剂的血流动力学效应。研究动物（n = 5）在分娩后立即接受单剂量表面活性剂，对照动物（n = 8）则未接受。在3小时、8小时和23小时使用微球，我们发现左心室输出量、有效体循环血流量、体循环至肺动脉导管未闭（PDA）分流，或脑或肾器官血流量均无显著差异。然而，两组均有较大的PDA分流（3小时和8小时时左心室输出量至肺的比例大于0.40 - 0.55），导致体循环灌注不足（小于80 ml/min/kg）。单剂量表面活性剂并未改善HMD治疗期间出现的心肌功能障碍以及低脑血流量和低肾血流量。
