Krauss A N, Fatica N, Lewis B S, Cooper R, Thaler H T, Cirrincione C, O'Loughlin J, Levin A, Engle M A, Auld P A
Perinatology Center, Cornell University Medical College, New York, NY.
Am J Dis Child. 1989 Jan;143(1):78-81. doi: 10.1001/archpedi.1989.02150130088021.
Pulmonary function tests, including measurements of arterial blood gas levels, total pulmonary compliance, and arterial-alveolar oxygen ratios, were performed in 38 ventilator-dependent preterm infants with respiratory distress syndrome who weighed less than 1500 g at birth. Twenty-seven had a physiologically significant patent ductus arteriosus (PDA). Twelve were assigned at random to receive three doses of intravenous indomethacin, 0.2 mg/kg per dose, on the fourth day of life. This treatment resulted in ductal closure in seven infants by the seventh day of life. Another concurrently observed group of 15 infants with PDA received no indomethacin. A third group of 11 infants lacked evidence of a PDA. Pulmonary function in the infants who received indomethacin did not differ significantly from that in the other two groups.
对38例出生时体重不足1500克、依赖呼吸机的呼吸窘迫综合征早产儿进行了肺功能测试，包括测量动脉血气水平、总肺顺应性和动脉-肺泡氧比值。27例有具有生理学意义的动脉导管未闭（PDA）。12例在出生后第4天被随机分配接受三剂静脉注射吲哚美辛，每剂0.2mg/kg。该治疗使7例婴儿在出生后第7天导管闭合。另一组同时观察的15例患有PDA的婴儿未接受吲哚美辛治疗。第三组11例婴儿没有动脉导管未闭的证据。接受吲哚美辛治疗的婴儿的肺功能与其他两组没有显著差异。
