Patni S, Flynn P, Wynen L P, Seager A L, Morgan G, White J O, Thornton C A
Department of Obstetrics and Gynaecology, Singleton Hospital, Swansea, UK.
BJOG. 2007 Nov;114(11):1326-34. doi: 10.1111/j.1471-0528.2007.01488.x. Epub 2007 Sep 27.
Toll-like receptors (TLR) have emerged as key upstream mediators of inflammation at many tissue sites in humans. Inflammatory processes are involved in the process of parturition suggesting that TLR activity within gestation-associated tissues might have an important role in the initiation and/or maintenance of normal term labour and in various pathological states of pregnancy such as infection-associated preterm labour. Either TLRs or their signalling molecules might be excellent therapeutic targets for prevention of preterm labour.
Toll样受体（TLR）已成为人类许多组织部位炎症的关键上游介质。炎症过程参与分娩过程，这表明妊娠相关组织中的TLR活性可能在正常足月分娩的启动和/或维持以及妊娠的各种病理状态（如感染相关的早产）中起重要作用。TLR或其信号分子可能是预防早产的极佳治疗靶点。
