Boughter John D, Bachmanov Alexander A
Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
BMC Neurosci. 2007 Sep 18;8 Suppl 3(Suppl 3):S3. doi: 10.1186/1471-2202-8-S3-S3.
This review focuses on behavioral genetic studies of sweet, umami, bitter and salt taste responses in mammals. Studies involving mouse inbred strain comparisons and genetic analyses, and their impact on elucidation of taste receptors and transduction mechanisms are discussed. Finally, the effect of genetic variation in taste responsiveness on complex traits such as drug intake is considered. Recent advances in development of genomic resources make behavioral genetics a powerful approach for understanding mechanisms of taste.
本综述聚焦于哺乳动物对甜味、鲜味、苦味和咸味味觉反应的行为遗传学研究。讨论了涉及小鼠近交系比较和遗传分析的研究及其对味觉受体和转导机制阐明的影响。最后,考虑了味觉反应性的遗传变异对药物摄入等复杂性状的影响。基因组资源开发的最新进展使行为遗传学成为理解味觉机制的有力方法。