哪些耳鸣患者能从经颅磁刺激中获益？
Which tinnitus patients benefit from transcranial magnetic stimulation?
作者信息
Kleinjung Tobias, Steffens Thomas, Sand Philipp, Murthum Tobias, Hajak Goeran, Strutz Juergen, Langguth Berthold, Eichhammer Peter
机构信息
Department of Otorhinolaryngology, University of Regensburg, Germany.
出版信息
Otolaryngol Head Neck Surg. 2007 Oct;137(4):589-95. doi: 10.1016/j.otohns.2006.12.007.
OBJECTIVES
Chronic tinnitus is associated with hyperactivity of the central auditory system. Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been proposed as a treatment for chronic tinnitus. This study determined the factors that predict a beneficial outcome with rTMS treatment.
STUDY DESIGN
Forty-five patients with chronic tinnitus underwent 10 sessions of low-frequency rTMS to their left auditory cortex. The treatment outcome was assessed with a tinnitus questionnaire. Therapeutic success was related to the patients' clinical characteristics.
RESULTS
A significant reduction in tinnitus complaints occurred after rTMS. In the questionnaire, 40% of the patients improved by five points or more. Treatment responders were characterized by shorter duration of tinnitus complaints and no hearing impairment.
CONCLUSION
Tinnitus-related neuroplastic changes might be less pronounced in patients with normal hearing and a short history of complaints. This could explain why those patients benefitted more from rTMS treatment.
目的
慢性耳鸣与中枢听觉系统的过度活跃有关。颞叶皮质的低频重复经颅磁刺激（rTMS）已被提议作为慢性耳鸣的一种治疗方法。本研究确定了预测rTMS治疗产生有益结果的因素。
研究设计
45例慢性耳鸣患者对其左侧听觉皮质进行了10次低频rTMS治疗。用耳鸣问卷评估治疗结果。治疗成功与患者的临床特征相关。
结果
rTMS治疗后耳鸣主诉显著减少。在问卷中，40%的患者改善了5分或更多。治疗反应者的特征是耳鸣主诉持续时间较短且无听力障碍。
结论
听力正常且主诉病史较短的患者中，耳鸣相关的神经可塑性变化可能不太明显。这可以解释为什么这些患者从rTMS治疗中获益更多。
Zotero 插件