Udaka Tsuyoshi, Suzuki Hideaki, Fujimura Takeyuki, Hiraki Nobuaki, Shiomori Teruo, Kitamura Takuro, Ueda Narihisa, Inaba Tsuyoshi, Fujino Yoshihisa
Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan.
Otolaryngol Head Neck Surg. 2007 Oct;137(4):669-73. doi: 10.1016/j.otohns.2007.04.016.
We administered a questionnaire survey to a working population in an attempt to clarify the relationships between self-reported nasal obstruction, observed apnea during sleep, and daytime sleepiness.
A total of 7980 daytime workers were asked to complete questionnaires about nasal obstruction, apnea during sleep, and daytime sleepiness. Of the 7702 responses, the data from 4818 subjects were analyzed. Nasal obstruction and observed apnea were graded into 3 categories. Daytime sleepiness was assessed by the Epworth Sleepiness Scale.
Subjects with chronic nasal obstruction had 5.22 and 2.17 times higher odds for having habitual observed apnea and excessive daytime sleepiness (EDS), respectively, compared with those without nasal obstruction (P < 0.001). After adjusting for 3 potential confounding factors (age, sex, and body mass index) and the presence of habitual observed apnea, odds ratios for having EDS decreased, but still remained significant.
Nasal obstruction is likely to cause daytime sleepiness, at least in part, by causing sleep-disordered breathing including apnea during sleep.
我们对在职人群进行了问卷调查，以试图阐明自我报告的鼻塞、睡眠中观察到的呼吸暂停与日间嗜睡之间的关系。
共7980名日间工作者被要求填写关于鼻塞、睡眠呼吸暂停和日间嗜睡的问卷。在7702份回复中，对4818名受试者的数据进行了分析。鼻塞和观察到的呼吸暂停被分为3类。日间嗜睡通过爱泼华嗜睡量表进行评估。
与无鼻塞者相比，慢性鼻塞患者习惯性观察到呼吸暂停和日间过度嗜睡（EDS）的几率分别高5.22倍和2.17倍（P<0.001）。在对3个潜在混杂因素（年龄、性别和体重指数）以及习惯性观察到的呼吸暂停进行校正后，出现EDS的优势比降低，但仍具有显著性。
鼻塞很可能至少部分地通过导致包括睡眠呼吸暂停在内的睡眠呼吸紊乱而引起日间嗜睡。
