角质形成细胞中的β肾上腺素能受体。
Beta adrenergic receptors in keratinocytes.
作者信息
Sivamani Raja K, Lam Susanne T, Isseroff R Rivkah
机构信息
Department of Dermatology, University of California, Davis, School of Medicine, Dermatology Research, TB 192, One Shields Avenue, Davis, CA 95616, USA.
出版信息
Dermatol Clin. 2007 Oct;25(4):643-53, x. doi: 10.1016/j.det.2007.06.012.
Abstract
Beta2 adrenergic receptors were identified in keratinocytes more than 30 years ago, but their function in the epidermis continues to be elucidated. Abnormalities in their expression, signaling pathway, or in the generation of endogenous catecholamine agonists by keratinocytes have been implicated in the pathogenesis of cutaneous diseases such as atopic dermatitis, vitiligo, and psoriasis. New studies also indicate that the beta2AR also modulates keratinocyte migration, and thus can function to regulate wound reepithelialization. This review focuses on the function of these receptors in keratinocytes and their contribution to cutaneous physiology and disease.
摘要
30多年前在角质形成细胞中发现了β2肾上腺素能受体，但其在表皮中的功能仍在不断阐明。其表达、信号通路异常，或角质形成细胞产生内源性儿茶酚胺激动剂异常，都与特应性皮炎、白癜风和银屑病等皮肤病的发病机制有关。新研究还表明，β2肾上腺素能受体还可调节角质形成细胞迁移，因此可发挥调节伤口再上皮化的作用。本文综述聚焦于这些受体在角质形成细胞中的功能及其对皮肤生理和疾病的作用。
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