Al Mamun Abdullah, Shao Chuxiao, Geng Peiwu, Wang Shuanghu, Xiao Jian
Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang 323000, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Burns Trauma. 2025 Jan 27;13:tkae072. doi: 10.1093/burnst/tkae072. eCollection 2025.
Neuroregulation during skin wound healing involves complex interactions between the nervous system and intricate tissue repair processes. The skin, the largest organ, depends on a complex system of nerves to manage responses to injury. Recent research has emphasized the crucial role of neuroregulation in maximizing wound healing outcomes. Recently, researchers have also explained the interactive contact between the peripheral nervous system and skin cells during the different phases of wound healing. Neurotransmitters and neuropeptides, once observed as simple signalling molecules, have since been recognized as effective regulators of inflammation, angiogenesis, and cell proliferation. The significance of skin innervation and neuromodulators is underscored by the delayed wound healing observed in patients with diabetes and the regenerative capabilities of foetal skin. Foetal skin regeneration is influenced by the neuroregulatory environment, immature immune system, abundant growth factors, and increased pluripotency of cells. Foetal skin cells exhibit greater flexibility and specialized cell types, and the extracellular matrix composition promotes regeneration. The extracellular matrix composition of foetal skin promotes regeneration, making it more capable than adult skin because neuroregulatory signals affect skin regeneration. The understanding of these systems can facilitate the development of therapeutic strategies to alter the nerve supply to the skin to enhance the process of wound healing. Neuroregulation is being explored as a potential therapeutic strategy for enhancing skin wound repair. Bioelectronic strategies and neuromodulation techniques can manipulate neural signalling, optimize the neuroimmune axis, and modulate inflammation. This review describes the function of skin innervation in wound healing, emphasizing the importance of neuropeptides released by sensory and autonomic nerve fibres. This article discusses significant discoveries related to neuroregulation and its impact on skin wound healing.
皮肤伤口愈合过程中的神经调节涉及神经系统与复杂的组织修复过程之间的复杂相互作用。皮肤作为人体最大的器官，依赖于一个复杂的神经系统来管理对损伤的反应。最近的研究强调了神经调节在最大化伤口愈合效果方面的关键作用。最近，研究人员还解释了伤口愈合不同阶段外周神经系统与皮肤细胞之间的相互作用。神经递质和神经肽，曾经被视为简单的信号分子，后来被认为是炎症、血管生成和细胞增殖的有效调节因子。糖尿病患者伤口愈合延迟以及胎儿皮肤的再生能力凸显了皮肤神经支配和神经调节因子的重要性。胎儿皮肤再生受到神经调节环境、不成熟的免疫系统、丰富的生长因子以及细胞多能性增加的影响。胎儿皮肤细胞表现出更大的灵活性和特殊的细胞类型，其细胞外基质组成促进再生。胎儿皮肤的细胞外基质组成促进再生，使其比成人皮肤更具再生能力，因为神经调节信号会影响皮肤再生。对这些系统的理解有助于开发治疗策略，改变皮肤的神经供应以增强伤口愈合过程。神经调节正被探索为一种增强皮肤伤口修复的潜在治疗策略。生物电子策略和神经调节技术可以操纵神经信号、优化神经免疫轴并调节炎症。本综述描述了皮肤神经支配在伤口愈合中的作用，强调了感觉和自主神经纤维释放的神经肽的重要性。本文讨论了与神经调节及其对皮肤伤口愈合的影响相关的重大发现。
