Takahashi Masaya, Kubo Shigeto, Kiryu Shigeru, Gee James, Hatabu Hiroto
Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
Eur J Radiol. 2007 Dec;64(3):367-74. doi: 10.1016/j.ejrad.2007.08.011. Epub 2007 Sep 27.
Understanding how the mammalian respiratory system works and how it changes in disease states and under the influence of drugs is frequently pursued in model systems such as small rodents. These have many advantages, including being easily obtained in large numbers as purebred strains. Studies in small rodents are valuable for proof of concept studies and for increasing our knowledge about disease mechanisms. Since the recent developments in the generation of genetically designed animal models of disease, one needs the ability to assess morphology and function in in vivo systems. In this article, we first review previous reports regarding thoracic imaging. We then discuss approaches to take in making use of small rodents to increase MR microscopic sensitivity for these studies and to establish MR methods for clinically relevant lung imaging.
了解哺乳动物呼吸系统的工作方式以及它在疾病状态下和药物影响下如何变化，这在诸如小型啮齿动物等模型系统中经常被研究。这些模型系统有许多优点，包括作为纯种品系很容易大量获得。在小型啮齿动物身上进行的研究对于概念验证研究以及增加我们对疾病机制的了解很有价值。自从最近在疾病基因设计动物模型的生成方面取得进展以来，人们需要有能力在体内系统中评估形态和功能。在本文中，我们首先回顾以前关于胸部成像的报告。然后我们讨论利用小型啮齿动物来提高这些研究的磁共振显微镜敏感性以及建立用于临床相关肺部成像的磁共振方法的途径。
