肺部超短回波时间（UTE）MR 成像：突变小鼠正常肺与肺气肿肺的比较。
Ultra-short echo time (UTE) MR imaging of the lung: comparison between normal and emphysematous lungs in mutant mice.
机构信息
Advanced Imaging Research Center, UT Southwestern Medical Center, 2201 Inwood Rd, Dallas, Texas 75390-8542, USA.
出版信息
J Magn Reson Imaging. 2010 Aug;32(2):326-33. doi: 10.1002/jmri.22267.
PURPOSE
To investigate the utility of ultra-short echo time (UTE) sequence as pulmonary MRI to detect non-uniform disruption of lung architecture that is typical of emphysema.
MATERIALS AND METHODS
MRI of the lungs was conducted with a three-dimensional UTE sequence in transgenic mice with severe emphysema and their wild-type littermates in a 3 Tesla clinical MR system. Measurements of the signal intensity (SI) and transverse relaxation time (T2*) of the lung parenchyma were performed with various echo times (TEs) ranging from 100 micros to 2 ms.
RESULTS
Much higher SI of the lung parenchyma was observed at an UTE of 100 micros compared with longer TEs. The emphysematous lungs had reduced SIs and T2* than the controls, in particular at end-expiratory phase. The results suggested that both SI and T2* in lung parenchyma measured with the method represent fractional volume of lung tissue.
CONCLUSION
The UTE imaging provided MR signal from the lung parenchyma. Moreover, the UTE sequence was sensitive to emphysematous changes and may provide a direct assessment of lung parenchyma. UTE imaging has the potential to assist detection of localized pathological destruction of lung tissue architecture in emphysema.
目的
研究超短回波时间（UTE）序列作为肺部 MRI 检测肺气肿典型的肺结构不均匀破坏的效用。
材料与方法
在 3T 临床磁共振系统中，对严重肺气肿的转基因小鼠及其野生型同窝仔鼠进行了三维 UTE 序列肺部 MRI 检查。对肺实质的信号强度（SI）和横向弛豫时间（T2*）进行了不同回波时间（TE）（100 微秒至 2 毫秒）的测量。
结果
与较长的 TE 相比，在 UTE 为 100 微秒时观察到肺实质的 SI 明显更高。与对照组相比，肺气肿肺的 SI 和 T2较低，特别是在呼气末相。结果表明，用该方法测量的肺实质的 SI 和 T2均代表肺组织的分数体积。
结论
UTE 成像提供了来自肺实质的磁共振信号。此外，UTE 序列对肺气肿变化敏感，可能提供对肺实质的直接评估。UTE 成像有可能有助于检测肺气肿中肺组织结构的局部病理性破坏。
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