Rajpathak Swapnil N, McGinn Aileen P, Strickler Howard D, Rohan Thomas E, Pollak Michael, Cappola Anne R, Kuller Lewis, Xue XiaoNan, Newman Anne B, Strotmeyer Elsa S, Psaty Bruce M, Kaplan Robert C
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 11375, USA.
Growth Horm IGF Res. 2008 Apr;18(2):166-73. doi: 10.1016/j.ghir.2007.08.004. Epub 2007 Sep 27.
Increasing evidence suggests that the insulin-like growth factor (IGF)-axis may play a role in glucose metabolism and may also be associated with systemic inflammation. The aim of this study was to evaluate the association of insulin-like growth factor-1 (IGF-I) and its binding proteins, IGFBP-1 and IGFBP-3, with glucose intolerance and inflammation among older adults. We conducted a cross-sectional analysis in a in a random subsample (n=922) of the Cardiovascular Health Study (CHS), a prospective cohort of men and women > or = 65 years. Mean IGFBP-1 levels were significantly lower in older adults with impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes compared to those with normal fasting and post-load glucose. High IGFBP-1 was associated with a reduced prevalence of IGT and IFG; the multivariable OR between extreme quartiles of IGFBP-1 was 0.60 (95% CI: 0.37, 0.95; p-trend: 0.03) for IGT and 0.41 (95% CI: 0.26, 0.64; p-trend: <0.01) for IFG. We did not find any significant association between IGF-I and glucose intolerance in this study and the association for IGFBP-3 was less clear. However, low levels of IGF-I and IGFBP-3 were associated with increased levels of markers of inflammation including C-reactive protein and interleukin-6 levels. We conclude that among adults > or = 65 years, low IGFBP-1 levels are associated with increased prevalence of glucose intolerance. We did not confirm prior associations of low IGF-I with glucose intolerance in this cohort of older individuals.
越来越多的证据表明，胰岛素样生长因子（IGF）轴可能在葡萄糖代谢中起作用，也可能与全身炎症相关。本研究的目的是评估胰岛素样生长因子-1（IGF-I）及其结合蛋白IGFBP-1和IGFBP-3与老年人葡萄糖不耐受和炎症之间的关联。我们对心血管健康研究（CHS）的一个随机子样本（n = 922）进行了横断面分析，CHS是一个针对年龄≥65岁男性和女性的前瞻性队列研究。与空腹和负荷后血糖正常的老年人相比，葡萄糖耐量受损（IGT）、空腹血糖受损（IFG）和糖尿病老年人的平均IGFBP-1水平显著降低。高IGFBP-1与IGT和IFG患病率降低相关；IGT的IGFBP-1极端四分位数之间的多变量OR为0.60（95%CI：0.37，0.95；p趋势：0.03），IFG为0.41（95%CI：0.26，0.64；p趋势：<0.01）。在本研究中，我们未发现IGF-I与葡萄糖不耐受之间存在任何显著关联，IGFBP-3的关联则不太明确。然而，低水平的IGF-I和IGFBP-3与包括C反应蛋白和白细胞介素-6水平在内的炎症标志物水平升高相关。我们得出结论，在年龄≥65岁的成年人中，低IGFBP-1水平与葡萄糖不耐受患病率增加相关。在这个老年人群队列中，我们未证实先前关于低IGF-I与葡萄糖不耐受的关联。
