Huang Chien-Ning, Chou Wen-Chih, Lin Li-Yun, Peng Chiung-Chi, Chyau Charng-Cherng, Chen Kuan-Chou, Peng Robert Y
School of Medicines, Chung-Shan Medical University, 110 Section 1, Chien-Kuo North Road, Taichung, Taiwan.
Biosystems. 2008 Jan;91(1):146-57. doi: 10.1016/j.biosystems.2007.08.005. Epub 2007 Aug 24.
We report here a mathematical model using computer simulation to solve the phase fractionation coefficient (f) of instantaneous insulin release on glucose infusion. By extensive model testing with the cited parameters obtained from the literature, the values of the factor f were shown to lie in range of 0.93+/-0.02 (mean+/-2S.D., n=15), indicating that the high pulsatile bolus of glucose by i.v. infusion may trigger acute insulin release (AIR) corresponding to a fraction of more than 90% of the stored insulin release in the first phase from the secretory granules of pancreatic beta cells. In addition, the value of the factor f was shown to be independent of both the glucose infusion method and the non-insulin-dependent uptake of glucose.
我们在此报告一种数学模型，该模型利用计算机模拟来求解葡萄糖输注时瞬时胰岛素释放的相分离系数（f）。通过使用从文献中获得的引用参数进行广泛的模型测试，结果表明因子f的值在0.93±0.02范围内（平均值±2标准差，n = 15），这表明静脉输注高脉冲性葡萄糖团块可能触发急性胰岛素释放（AIR），其对应于胰腺β细胞分泌颗粒在第一阶段储存胰岛素释放的90%以上。此外，因子f的值显示出与葡萄糖输注方法和葡萄糖的非胰岛素依赖性摄取均无关。
