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表现为胸椎压迫的骨外硬膜外多发性骨髓瘤

Extraosseous epidural multiple myeloma presenting with thoracic spine compression.

作者信息

Okacha Naama, Chrif Elasri, Brahim Elmostarchid, Ali Akhaddar, Abderrahman Elbouzidi, Gazzaz Miloudi, Adil Belhachmi, Bouchaib Kadiri, Mohamed Boucetta

机构信息

Department of Neurosurgery, Mohammed V Military Hospital, 282 hay el menzeh, CYM, Rabat, Morocco.

出版信息

Joint Bone Spine. 2008 Jan;75(1):70-2. doi: 10.1016/j.jbspin.2007.01.044. Epub 2007 Aug 28.

Abstract

Multiple myeloma is a hematopoetic disorder and multicentric disease, with the most common localisation being the spine. A 47-year-old male presented with progressive paraplegia, superficial and deep sensory disturbance below the level of T4. Spinal magnetic resonance image showed an epidural mass compressing the spinal cord at the level of T4-T6 with intact bone structure. The patient underwent surgical T4-T6 posterior spinal decompression. Microscopic examination and immunohistochemical studies confirmed the diagnosis of multiple myeloma of kappa subtype. Immunoelectrophoresis revealed the presence of immunoglobulin G kappa. The patient was subsequently started on steroids and chemotherapy for myeloma. Extraosseous epidural tumors causing compression myelopathy without evidence of destruction or collapse of vertebral bodies are relatively rare; to our knowledge only four cases have been reported in English literature.

摘要

多发性骨髓瘤是一种造血系统疾病和多中心性疾病,最常见的发病部位是脊柱。一名47岁男性患者出现进行性截瘫,T4水平以下有浅感觉和深感觉障碍。脊髓磁共振成像显示在T4 - T6水平有一个硬膜外肿块压迫脊髓,骨质结构完整。该患者接受了T4 - T6后路脊髓减压手术。显微镜检查和免疫组化研究确诊为κ亚型多发性骨髓瘤。免疫电泳显示存在免疫球蛋白G κ。患者随后开始接受针对骨髓瘤的类固醇和化疗。导致压迫性脊髓病而无椎体破坏或塌陷证据的骨外硬膜外肿瘤相对罕见;据我们所知,英文文献中仅报道过4例。

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