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表现为脊髓压迫症的骨外硬膜外IgD骨髓瘤

Extraosseous epidural IgD myeloma presenting with compression myelopathy.

作者信息

Watanabe Y, Endou A, Ooi S, Matsushima E, Shimisu Y, Nakashima K

机构信息

Department of Neurology, Matsue Red Cross Hospital, Japan.

出版信息

Psychiatry Clin Neurosci. 2000 Dec;54(6):665-7. doi: 10.1046/j.1440-1819.2000.00767.x.

Abstract

An 85-year-old man presented with acute transverse myelopathy: flaccid paraplegia, superficial and deep sensory disturbance below Th6 and loss of urinary sensation. Spinal magnetic resonance image showed an epidural mass compressing the spinal cord at the level of C7 to Th2. Immunoelectrophoresis revealed the presence of immunoglobulin D (IgD)-lambda M protein. Chemotherapy markedly improved both the haematologic aspect and tumor size, but not the motor deficit. In IgD myeloma, extraosseous spreads occur frequently, but extraosseous epidural tumors causing compression myelopathy are relatively rare. To our knowledge, this is the fourth report of cases.

摘要

一名85岁男性出现急性横贯性脊髓病:弛缓性截瘫、T6以下深浅感觉障碍及尿感觉丧失。脊髓磁共振成像显示硬膜外肿块在C7至T2水平压迫脊髓。免疫电泳显示存在免疫球蛋白D(IgD)-λM蛋白。化疗显著改善了血液学指标和肿瘤大小,但运动功能障碍未改善。在IgD骨髓瘤中,骨外播散很常见,但导致压迫性脊髓病的骨外硬膜外肿瘤相对少见。据我们所知,这是第四例相关病例报告。

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