Sabouraud Sabine, Testud François, Descotes Jacques, Benevent Monique, Soglu Gilbert
Lyon Poison Center, Toxicovigilance Unit, Lyon, France.
Clin Toxicol (Phila). 2008 Mar;46(3):267-9. doi: 10.1080/15563650701639014.
A 37-year-old man was admitted to hospital after complaining of abdominal pain for the past two weeks. On admission the abdominal radiograph showed multiple radio-opaque flecks dispersed throughout the gastrointestinal tract. Blood testing showed hemoglobin level 8.7 g/dL and a blood lead level of 112.4 microg/dL. The family interview revealed that the patient had pica-like behavior since childhood. He was a site foreman and had been ingesting pieces of roofing plates for a few weeks. The patient was treated with laxatives and CaNa(2)EDTA therapy was initiated. The blood lead level then dropped to 69.9 microg/dL. The patient received two subsequent courses of oral succimer and the blood lead level decreased to 59 microg/dL 21 days after the first course. The follow-up abdominal X-ray 20 days after the first examination was normal. Four months later, an outpatient follow-up visit showed a blood lead level within normal limits (14.5 microg/dL) and a psychiatric follow-up was initiated. Lead poisoning following the ingestion of lead-containing foreign bodies is particularly rare in adults, while it is sometimes observed in children. Pica behavior is a well-identified risk factor of lead intoxication in children but is quite exceptional in adults, where it is usually considered to be a psychiatric condition. Other unusual sources of lead poisoning include the ingestion of lead bullets, ceramic lead glaze or glazed earthenware, lead-contaminated candies, ethnic or herbal remedies.
一名37岁男性在诉说过去两周腹痛后入院。入院时腹部X光片显示整个胃肠道有多个不透射线的斑点。血液检测显示血红蛋白水平为8.7 g/dL,血铅水平为112.4微克/分升。家庭访谈显示患者自童年起就有异食癖样行为。他是一名工地 foreman,几周来一直在吞食屋顶板碎片。患者接受了泻药治疗,并开始进行CaNa₂EDTA治疗。血铅水平随后降至69.9微克/分升。患者随后接受了两个疗程的口服二巯基丁二酸治疗,第一个疗程后21天血铅水平降至59微克/分升。首次检查20天后的随访腹部X光片正常。四个月后,门诊随访显示血铅水平在正常范围内(14.5微克/分升),并开始进行精神科随访。摄入含铅异物后导致的铅中毒在成年人中尤为罕见,而在儿童中有时会观察到。异食癖行为是儿童铅中毒的一个明确风险因素,但在成年人中相当罕见,在成年人中通常被认为是一种精神疾病。其他不寻常的铅中毒来源包括摄入铅弹、陶瓷铅釉或釉面陶器、铅污染的糖果、民族或草药疗法。 (注:原文中“site foreman”不太明确准确意思,暂保留英文)