神经细胞黏附分子-180表达作为结直肠癌的预后标准：可行与否？
Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?
作者信息
Tascilar Oge, Cakmak Güldeniz Karadeniz, Tekin Ishak Ozel, Emre Ali-Ugur, Ucan Bulent Hamdi, Irkorucu Oktay, Karakaya Kemal, Gül Mesut, Engin Hüseyin Bülent, Comert Mustafa
机构信息
Department of Surgery, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey.
出版信息
World J Gastroenterol. 2007 Nov 7;13(41):5476-80. doi: 10.3748/wjg.v13.i41.5476.
AIM
To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.
METHODS
Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.
RESULTS
Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up.
CONCLUSION
As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.
目的
评估神经细胞黏附分子（NCAM）-180在新鲜肿瘤组织样本中的表达频率，并探讨NCAM-180在常规临床实践中的预后价值。
方法
本研究纳入了26例结直肠癌患者（16例男性，10例女性）。对每个标本的新鲜肿瘤组织样本和肉眼可见健康的近端切缘进行NCAM-180表达的流式细胞术分析。
结果
流式细胞术分析确定了肉眼可见健康的结直肠组织全组织样本中NCAM-180的表达。然而，仅1例（3.84%）高分化II期疾病患者的NCAM-180表达呈阳性，该患者在30个月的随访中无疾病活动。
结论
由于我们系列研究中的病例数量有限，可能无法进行概括，但由于NCAM-180表达发生率极低，在临床实践中将其作为结直肠癌的预后标志物进行常规应用似乎不可行且不具有成本效益。
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