Huige W M, Beekhuis W H, Rijneveld W J, Schrage N, Remeijer L
Rotterdam Eye Hospital, Cornea Service.
Doc Ophthalmol. 1991;78(3-4):169-75. doi: 10.1007/BF00165677.
Clinical observation of eight patients with superficial stromal precipitation of calcium phosphate is presented. In all cases the predisposing factors for the formation of these depositions were: epithelial defects and the combined use of topical dexamethasone phosphate or prednisolone phosphate with topical beta-blocking agents. In two patients the medication that gave rise to these precipitates was used without preservatives, suggesting that the medication itself and not the preservatives contribute to the deposits. Discontinuance of simultaneous administration of the steroids and beta-blocking agents prevented further formation of precipitates. The authors suggest an interaction between simultaneously given steroid and beta-blocking agents, giving rise to calcium phosphate precipitates when an epithelial defect is present which allows easy access to the superficial corneal stroma.
本文报告了8例浅表性基质磷酸钙沉着患者的临床观察结果。在所有病例中，这些沉积物形成的诱发因素为：上皮缺损以及局部使用磷酸地塞米松或磷酸泼尼松龙与局部β受体阻滞剂联合应用。在2例患者中，引发这些沉淀物的药物未添加防腐剂，这表明是药物本身而非防腐剂导致了沉积物的形成。停用类固醇和β受体阻滞剂的同时给药可防止沉淀物进一步形成。作者认为，同时给予的类固醇和β受体阻滞剂之间存在相互作用，当存在上皮缺损，使浅表角膜基质易于接触时，就会产生磷酸钙沉淀物。
