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Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain.

作者信息

Brunger Axel T, Breidenbach Mark A, Jin Rongsheng, Fischer Audrey, Santos Jose S, Montal Mauricio

机构信息

Department of Molecular and Cellular Physiology, Stanford University, Stanford, California, USA.

出版信息

PLoS Pathog. 2007 Sep 7;3(9):1191-4. doi: 10.1371/journal.ppat.0030113.

DOI:10.1371/journal.ppat.0030113
PMID:17907800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1994969/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c3/1994969/4b7b1813e5f2/ppat.0030113.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c3/1994969/ca4e38de8c33/ppat.0030113.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c3/1994969/4b7b1813e5f2/ppat.0030113.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c3/1994969/ca4e38de8c33/ppat.0030113.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c3/1994969/4b7b1813e5f2/ppat.0030113.g002.jpg

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An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.通过高通量鉴定肉毒杆菌神经毒素A拮抗剂发现的体外和体内脱节现象。
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2602-7. doi: 10.1073/pnas.0611213104. Epub 2007 Feb 9.
3
Mechanism of substrate recognition by botulinum neurotoxin serotype A.
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Activity of botulinum neurotoxin X and its structure when shielded by a non-toxic non-hemagglutinin protein.肉毒杆菌神经毒素X的活性及其被无毒非血凝素蛋白屏蔽时的结构。
Commun Chem. 2024 Aug 13;7(1):179. doi: 10.1038/s42004-024-01262-8.
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Botulinum neurotoxin X lacks potency in mice and in human neurons.肉毒神经毒素 X 在小鼠和人神经元中没有效价。
mBio. 2024 Mar 13;15(3):e0310623. doi: 10.1128/mbio.03106-23. Epub 2024 Feb 13.
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