Herman Keith C, Ostrander Rick, Walkup John T, Silva Susan G, March John S
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287-3325, USA.
J Consult Clin Psychol. 2007 Oct;75(5):716-28. doi: 10.1037/0022-006X.75.5.716.
A latent profile analysis was conducted on the co-occurring symptoms of 423 adolescents diagnosed with major depressive disorder as part of the Treatment for Adolescents with Depression Study (TADS), a multisite, randomized treatment trial. The participants had a mean (SD) age of 14.6 (1.5) years; of the sample, 45.6% was male and 73.8% was white. Scores on the primary subscales of Conners' Parent Rating Scale--Revised were used as indicators in the analysis. Five classes of symptoms best described the clinical presentation of adolescents enrolled in the TADS. Of the adolescents in the sample, 80% were assigned to classes with clinically significant elevations on 1 or more subscales of the Children's Depression Rating Scale--Revised. The 5 classes met empirical criteria for distinctiveness and were validated against clinical diagnoses, child-rated symptoms, and clinician-rated functional impairment. The findings are consistent with prior studies that showed a high rate of co-occurring symptoms among depressed adolescents. The discussion focuses on understanding subtypes and comorbidity in adolescent depression as well as the implications for treatment and for prevention.
作为青少年抑郁症治疗研究（TADS）的一部分，对423名被诊断为重度抑郁症的青少年的共现症状进行了潜在剖面分析。TADS是一项多地点随机治疗试验。参与者的平均（标准差）年龄为14.6（1.5）岁；样本中45.6%为男性，73.8%为白人。分析中使用了康纳斯父母评定量表修订版主要分量表的得分作为指标。五类症状最能描述参与TADS的青少年的临床表现。样本中的青少年中，80%被分到在儿童抑郁评定量表修订版的1个或更多分量表上有临床显著升高的类别。这五类症状符合独特性的实证标准，并通过临床诊断、儿童自评症状和临床医生评定的功能损害进行了验证。这些发现与之前显示抑郁青少年中共现症状发生率很高的研究一致。讨论集中在理解青少年抑郁症的亚型和共病情况以及对治疗和预防的意义。
