Seliatitskaia V G, Strebkova T M, Mertvetsov N P, Shul'ga V A, Kolpakov M G
Probl Endokrinol (Mosk). 1975 Jul-Aug;21(4):78-82.
A study was made of the capacity of the cytoplasmic cell fraction of rat kidney to bind H3-aldosterone, depending on the level of Na uptake with food, and, consequently, on the intensity of aldosterone secretion by the adrenal glands. It was shown by Sketchard's method that there existed in the cytoplasmic fraction of the kidney cells of rats with a high and low level of aldosterone secretion two classes of receptors binding aldosterone with a different degree of affinity. The number of binding sites for aldosterone in the 1st class of receptors, more specific for mineralocorticoids in the animals with a low level of aldosterone secretion (Na loading), was double that in comparison with the animals with a high level of aldosterone (Na deficiency). It is supposed that an increased aldosterone concentration in the organism in Na deficiency increased the transport of the specific hormone-receptor complex from the cytoplasm into the nucleus.
研究了大鼠肾脏细胞质细胞部分结合H3-醛固酮的能力，该能力取决于食物中钠的摄取水平，进而取决于肾上腺醛固酮分泌的强度。通过斯卡查德方法表明，醛固酮分泌水平高和低的大鼠肾细胞细胞质部分存在两类以不同亲和力结合醛固酮的受体。在醛固酮分泌水平低（钠负荷）的动物中，第一类受体中醛固酮的结合位点数量，与醛固酮水平高（钠缺乏）的动物相比，是其两倍。据推测，钠缺乏时机体中醛固酮浓度增加，会使特定激素-受体复合物从细胞质向细胞核的转运增加。
