Hraschek A, Debreczeni L, Endröczi E
Endokrinologie. 1975 Feb;64(3):311-5.
An increase of the sodium concentration produced a diminished binding of labeled aldosterone to kidney receptors in both in vivo and in vitro conditions. The elevation of potassium level did not change the binding capacity of kidney nuclear receptors for aldosterone. Hypernatraemia-induced decrease of aldosterone uptake was significant in the nuclear fraction of both medullary and cortical region of the kidney but did not show remarkable changes in the uptake of cytosol fraction. The transfer of aldosterone from cytosol into the nuclear compartment seems to be changed by the alteration of extracellular sodium concentration.
在体内和体外条件下，钠浓度的升高均导致标记的醛固酮与肾脏受体的结合减少。钾水平的升高并未改变肾脏核受体对醛固酮的结合能力。高钠血症引起的醛固酮摄取减少在肾脏髓质和皮质区域的核部分中均很显著，但在胞质溶胶部分的摄取中未显示出明显变化。细胞外钠浓度的改变似乎改变了醛固酮从胞质溶胶向核区室的转运。
