雌激素与骨骼：破骨细胞成为焦点。
Estrogen and bone: osteoclasts take center stage.
作者信息
Novack Deborah V
机构信息
Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Cell Metab. 2007 Oct;6(4):254-6. doi: 10.1016/j.cmet.2007.09.007.
PMID:17908554
Abstract
Loss of estrogen at menopause causes osteoporosis in many women, but estrogen's relevant cellular target in this process has remained unclear. In a recent study in Cell, Kato and colleagues (Nakamura et al., 2007) selectively ablate estrogen receptor alpha in osteoclasts and demonstrate that estrogen directly induces osteoclast apoptosis.
摘要
绝经后雌激素缺乏会导致许多女性患骨质疏松症，但在此过程中雌激素相关的细胞靶点仍不清楚。在《细胞》杂志最近的一项研究中，加藤及其同事（中村等人，2007年）选择性地去除破骨细胞中的雌激素受体α，并证明雌激素直接诱导破骨细胞凋亡。
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