N，N-二烷基氨基异丙基-和O-烷基异丙基-2-（1-烷基-2-氧代亚丙基）膦酰肼肟的一种新颖高效合成方法——潜在的海洋鱼类毒素类似物。第1部分。

A novel and efficient synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes--potential marine fish toxin analogues. Part 1.

作者信息

Kumar Rajesh, Gupta Arvind K, Kaushik Mahabir P

机构信息

Process Technology Development Division, Defence R and D Establishment, Jhansi Road, Gwalior 474002 (MP) India.

出版信息

Molecules. 2007 Jul 9;12(7):1334-40. doi: 10.3390/12071334.

DOI:10.3390/12071334

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6149394/

Abstract

A novel and efficient method for the synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes (4) using activated silica as dehydrating agent has been developed. The reaction involves the condensation of substituted diacetyl monoxime and N,N-dialkylaminoisopropyl-phosphono hydrazide or O-alkylisopropylphosphono hydrazides and gave the corresponding analogues of a naturally occurring fish toxin in excellent yields under mild conditions.

摘要

已开发出一种新颖且高效的方法，以活性二氧化硅作为脱水剂来合成N,N-二烷基氨基异丙基-和O-烷基异丙基-2-(1-烷基-2-氧代亚丙基)膦酰肼肟(4)。该反应涉及取代的二乙酰单肟与N,N-二烷基氨基异丙基膦酰肼或O-烷基异丙基膦酰肼的缩合反应，并在温和条件下以优异的产率得到了一种天然存在的鱼毒素的相应类似物。

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