一条通往具有生物学意义的吡喃查耳酮天然产物的高效快速合成路线。
An efficient and rapid synthetic route to biologically interesting pyranochalcone natural products.
作者信息
Lee Yong Rok, Wang Xue, Xia Likai
机构信息
School of Chemical Engineering and Technology, Yeungnam University, Gyeongsan 712-749, Korea.
出版信息
Molecules. 2007 Jul 12;12(7):1420-9. doi: 10.3390/12071420.
Abstract
An efficient and concise total synthesis of naturally occurring pyranochalcones was achieved from readily available 2,4-dihydroxyacetophenone and 2,4-dihydroxy-6-methoxyacetophenone. The key steps in the synthetic strategy were ethylenediamine diacetate-catalyzed benzopyran formation and aldol reactions.
摘要
以易得的2,4-二羟基苯乙酮和2,4-二羟基-6-甲氧基苯乙酮为原料，实现了天然存在的吡喃查耳酮的高效简洁全合成。合成策略中的关键步骤是乙二胺二乙酸酯催化的苯并吡喃形成反应和羟醛缩合反应。
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