Narender Tadigoppula, Gupta Suman
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226 001, India.
Bioorg Med Chem Lett. 2004 Aug 2;14(15):3913-6. doi: 10.1016/j.bmcl.2004.05.071.
2',2'-Dimethyl chromeno dihydrochalcones are very rare in nature as plant secondary metabolites. Recently we have reported three such compounds from the plant Crotalaria ramosissima. Chromeno dihydrochalcones contain a 2',2'-dimethyl benzopyran system, which are frequently encountered in many natural products and exhibit a variety of biological activities. We here report the strategy to conveniently synthesize naturally occurring chromeno dihydrochalcones by biogenetic type pyridine or Amberlyst-15 catalyzed chromenylation of dihydrochalcones and in vitro antileishmanial activity of chromeno dihydrochalcones and their intermediates.
2',2'-二甲基色烯二氢查耳酮作为植物次生代谢产物在自然界中非常罕见。最近我们报道了从植物多枝猪屎豆中分离出的三种此类化合物。色烯二氢查耳酮含有一个2',2'-二甲基苯并吡喃体系，该体系在许多天然产物中经常出现并具有多种生物活性。我们在此报告了通过生物合成型吡啶或Amberlyst-15催化二氢查耳酮的色烯化反应方便地合成天然存在的色烯二氢查耳酮的策略，以及色烯二氢查耳酮及其中间体的体外抗利什曼原虫活性。
