Shi Yang
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Rev Genet. 2007 Nov;8(11):829-33. doi: 10.1038/nrg2218.
The discovery of an increasing number of histone demethylases has highlighted the dynamic nature of the regulation of histone methylation, a key chromatin modification that is involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered glimpses into the specific biological roles of these enzymes and their potential connections to human diseases. These advances have also catalysed a resurgence of interest in epigenetic regulators as potential therapeutic targets.
越来越多组蛋白去甲基化酶的发现凸显了组蛋白甲基化调控的动态性质，组蛋白甲基化是一种关键的染色质修饰，参与真核生物基因组和基因调控。最近一系列研究让我们得以初步了解这些酶的具体生物学作用及其与人类疾病的潜在联系。这些进展还促使人们对作为潜在治疗靶点的表观遗传调节剂重新产生兴趣。
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