Gupta S, Raina R K, Samotra K, Gupta K L
Department of Pharmacology, Government Medical College, Jammu.
Indian J Chest Dis Allied Sci. 1991 Jan-Mar;33(1):1-8.
Pharmacokinetics of a sustained release (SR) and conventional formulations of theophylline plus hydroxyethyltheophylline was compared with tablet aminophylline. Time concentration curve of serum theophylline with the three formulations after single and multiple dosage schedules revealed significantly retarded absorption with the SR preparation. SR tablet was also seen to produce uniform steady state levels with fluctuation of serum concentrations within the therapeutic range for a duration of over 12 hours. In comparison, aminophylline and conventional theophylline hydroxyethyltheophylline tablets produced sharp swings in steady state levels with trough levels dipping to subtherapeutic concentrations within 4-6 hours. SR formulation, therefore, is likely provide consistent serum levels and better therapeutic control in comparison to the other two conventional tablets.
将茶碱加羟乙茶碱的缓释（SR）制剂和常规制剂的药代动力学与氨茶碱片进行了比较。单次和多次给药方案后，三种制剂的血清茶碱时间浓度曲线显示，SR制剂的吸收明显延迟。还观察到SR片能产生均匀的稳态水平，血清浓度在治疗范围内波动超过12小时。相比之下，氨茶碱和常规的茶碱羟乙茶碱片的稳态水平出现急剧波动，在4 - 6小时内谷浓度降至亚治疗浓度。因此，与其他两种常规片剂相比，SR制剂可能提供更稳定的血清水平和更好的治疗控制。
