Morphometric study of the ascending aorta in human fetuses.

The present study was performed on 128 spontaneously aborted human fetuses, aged 15-34 weeks, to compile normative data for ascending aorta dimensions at varying gestational age. Using anatomical dissection, digital-image analysis (system of Leica QWin Pro 16) and statistical analysis (ANOVA, regression analysis) a range of measurements (Length, original and terminal external diameters, volume) for the ascending aorta during gestation was examined. No significant gender differences were found (P > 0.05). The growth curves of the best fit for the plot for each morphometric feature against gestational age were generated. Both the Length and external diameters of the ascending aorta were found to increase in a linear fashion throughout gestation. The Length ranged from 2.63 +/- 0.42 to 10.80 +/- 1.49mm, according to the linear function y = -4.678 + 0.4647x +/- 0.8447 (r = 0.95). The original external diameter ranged from 2.02 +/- 0.26 to 6.84 +/- 0.63 mm, according to the linear model y = -2.103 + 0.2684x +/- 0.3958 (r = 0.97). The terminal external diameter ranged from 1.73 +/- 0.20 to 6.29 +/- 0.52 mm, with accordance to the linear function y = -2.354 + 0.2567x +/- 0.3826 (r = 0.97). The ascending aorta volume ranged from 7.56 +/- 2.65 to 370.99 +/- 105.42 mm3, according to the quadratic function y = 373.1 - 43.38x + 1.30x(2) +/- 24.51 (R2 = 0.89). The growth curves generated from my data might be useful as a reference for fetal echocardiographers in the detection of some congenital cardiovascular abnormalities.