Szpinda M
Department of Normal Anatomy, the Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University, Toruń, Poland.
Folia Morphol (Warsz). 2007 May;66(2):131-7.
The present study was performed on 128 spontaneously aborted human foetuses aged 15-34 weeks in order to establish normal values for thoracic aorta dimensions at various gestational ages. Using anatomical dissection, digital-image analysis (the Leica QWin Pro 16 system) and statistical analysis (ANOVA, regression analysis) the growth of the length, the original and terminal external diameters and the volume of the thoracic aorta during gestation was examined. No significant gender differences were found (p>0.05). The growth curves were generated of the best fit for the plot for each morphometric feature against gestational age. Both the length and external diameters of the thoracic aorta increased in proportion to the advance in foetal age. The length ranged from 12.49+/-1.85 mm to 48.82+/-6.31 mm according to the linear function y=-19.654+2.0512x+/-3.5168. The original external diameter ranged from 1.25+/-0.28 mm to 5.65+/-0.48 mm according to the linear fashion y=-2.3834+0.2367x+/-0.3850. The terminal external diameter ranged from 1.15+/-0.26 mm to 5.18+/-0.45 mm, in agreement with the linear model y=-2.1438+0.2156x+/-0.3555 (r=0.96, p<0.001 for each feature). The volume of the thoracic aorta ranged from 15.75+/-8.06 mm3 to 1158.01+/-301.85 mm3 according to the quadratic function y=1376.2-154.42x+4.419x2+/-125.6 (R2=0.90). The growth curves generated from my data may be useful as a reference for foetal echocardiographers, who must distinguish abnormal from normal foetal development.
本研究对128例孕15 - 34周自然流产的人类胎儿进行，以确定不同孕周胸主动脉尺寸的正常值。通过解剖、数字图像分析（徕卡QWin Pro 16系统）和统计分析（方差分析、回归分析），研究了孕期胸主动脉长度、起始和终末外径以及体积的生长情况。未发现显著的性别差异（p>0.05）。针对每个形态学特征与孕周的关系绘制了最佳拟合生长曲线。胸主动脉的长度和外径均随胎儿年龄的增长而成比例增加。根据线性函数y = -19.654 + 2.0512x ± 3.5168，长度范围为12.49 ± 1.85 mm至48.82 ± 6.31 mm。根据线性方式y = -2.3834 + 0.2367x ± 0.3850，起始外径范围为1.25 ± 0.28 mm至5.65 ± 0.48 mm。终末外径范围为1.15 ± 0.26 mm至5.18 ± 0.45 mm，符合线性模型y = -2.1438 + 0.2156x ± 0.3555（每个特征的r = 0.96，p<0.001）。根据二次函数y = 1376.2 - 154.42x + 4.419x2 ± 125.6，胸主动脉体积范围为15.75 ± 8.06 mm3至1158.01 ± 301.85 mm3（R2 = 0.90）。从我数据生成的生长曲线可能对胎儿超声心动图医生有用，他们必须区分胎儿发育的正常与异常情况。
