曲霉中3-甲基邻香兰素合酶（MOS）的表征：聚酮生物合成过程中还原释放机制的首次观察。
Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis.
作者信息
Bailey Andrew M, Cox Russell J, Harley Kate, Lazarus Colin M, Simpson Thomas J, Skellam Elizabeth
机构信息
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, UK BS8 1UG.
出版信息
Chem Commun (Camb). 2007 Oct 21(39):4053-5. doi: 10.1039/b708614h. Epub 2007 Jul 25.
DOI:10.1039/b708614h
PMID:17912413
Abstract
Isolation and sequencing of a PKS gene isolated from xenovulene-producing cultures of Acremonium strictum indicated the presence of NT-, KS-, AT-, PT-, C-MeT- and R-domains; heterologous expression in Aspergillus oryzae resulted in the production of 3-methylorcinaldehyde, demonstrating the role of the terminal reductase domain in product release.
摘要
从紧密枝顶孢产生异戊二烯的培养物中分离出的一个聚酮合酶（PKS）基因的分离和测序表明存在NT-、KS-、AT-、PT-、C-MeT-和R-结构域；在米曲霉中的异源表达导致了3-甲基邻苯二甲醛的产生，证明了末端还原酶结构域在产物释放中的作用。
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