Oliver M, Ragot C, Savini H, Chianéa D, Navarro L, Moalic J-L
Laboratoire de biochimie, Hôpital d'instruction des armées Laveran, Marseille.
Ann Biol Clin (Paris). 2007 Sep-Oct;65(5):577-80.
In biochemistry laboratory, monoclonal immunoglobulins are frequently found. They can lead to analytical interferences which are difficult to anticipate. In this case reports, a monoclonal immunoglobulin M with cryoglobulin effect has been responsible of false result of protein electrophoresis because of the whole precipitation of the monoclonal immunoglobulin. This case report allows us to remember the interferences caused by monoclonal immunoglobulins and that clinicians should be aware of these aspects of paraproteins and contacting the laboratory when encountering unexpected results.
在生物化学实验室中，经常会发现单克隆免疫球蛋白。它们可能导致难以预测的分析干扰。在本病例报告中，一种具有冷球蛋白效应的单克隆免疫球蛋白M因单克隆免疫球蛋白的整体沉淀导致蛋白质电泳出现假结果。本病例报告让我们记住单克隆免疫球蛋白引起的干扰，临床医生应了解这些副蛋白的相关情况，并在遇到意外结果时与实验室联系。
