社区环境中丙型肝炎病毒通过针刺伤传播的情况。
Transmission of hepatitis C virus by needle-stick injury in community settings.
作者信息
Haber Paul S, Young Margaret M, Dorrington Lloyd, Jones Andrew, Kaldor John, De Kanzow Sophie, Rawlinson William D
机构信息
Royal Prince Alfred Hospital and Discipline of Medicine, University of Sydney, Sydney, New South Wales, Australia.
出版信息
J Gastroenterol Hepatol. 2007 Nov;22(11):1882-5. doi: 10.1111/j.1440-1746.2006.04568.x.
BACKGROUND
Hepatitis C virus (HCV) is predominantly transmitted by blood-to-blood contact, typically by sharing of needles by injecting drug users. Discarded needles could act as a vector for transmission of this infection.
METHODS
Two cases of HCV seroconversion following a needle-stick injury in a community setting were identified. The effects of specimen processing and storage conditions on detection of HCV RNA were assessed to provide information about the likelihood of discarded needles containing infectious HCV.
RESULTS
Consistent with a role for discarded needles in viral transmission, in vitro studies demonstrated that viral load declined by less than one log following storage for 24 h.
CONCLUSION
All needle-stick injuries should be promptly investigated by serology and HCV-PCR.
背景
丙型肝炎病毒（HCV）主要通过血液接触传播，通常是注射吸毒者共用针头所致。丢弃的针头可能成为这种感染传播的媒介。
方法
在社区环境中，发现了两例针刺伤后丙型肝炎病毒血清学转换的病例。评估了样本处理和储存条件对HCV RNA检测的影响，以提供有关丢弃的针头含有传染性HCV可能性的信息。
结果
体外研究表明，与丢弃的针头在病毒传播中的作用一致，储存24小时后病毒载量下降不到一个对数。
结论
所有针刺伤都应立即进行血清学和HCV-PCR检测。
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