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麦克尔病的药理和营养治疗试验。

Pharmacological and nutritional treatment trials in McArdle disease.

作者信息

Quinlivan R M, Beynon R J

机构信息

The Wolfson Centre for Inherited Neuromuscular Diseases (CIND), Robert Jones and Agnes Hunt, NHS Trust, Oswestry, UK.

出版信息

Acta Myol. 2007 Jul;26(1):58-60.

Abstract

A systematic review of evidence for randomised controlled trials using pharmacologic and nutritional therapies in McArdle disease was undertaken. Primary outcome measures included any objective assessment of exercise endurance. Secondary outcome measures included changes in metabolic parameters, subjective measures such as quality of life scores and adverse outcomes. Ten randomised controlled trials were identified. Two trials low dose creatine (60 mg/kg/day) and oral sucrose 75 g prior to exercise demonstrated a positive effect.

摘要

对使用药物和营养疗法治疗麦克尔迪氏病的随机对照试验证据进行了系统评价。主要结局指标包括对运动耐力的任何客观评估。次要结局指标包括代谢参数的变化、主观指标如生活质量评分和不良结局。共确定了10项随机对照试验。两项试验表明,运动前服用低剂量肌酸(60毫克/千克/天)和口服75克蔗糖有积极效果。

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