弗雷明汉心脏研究，正朝着成为心血管遗传流行病学的金标准迈进？
The Framingham Heart Study, on its way to becoming the gold standard for Cardiovascular Genetic Epidemiology?
作者信息
Jaquish Cashell E
机构信息
Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, MSC 7936 Suite 10018, Bethesda, MD 20892-7936, USA.
出版信息
BMC Med Genet. 2007 Oct 4;8:63. doi: 10.1186/1471-2350-8-63.
The Framingham Heart Study, founded in 1948 to examine the epidemiology of cardiovascular disease in a small town outside of Boston, has become the worldwide standard for cardiovascular epidemiology. It is among the longest running, most comprehensively characterized multi-generational studies in the world. Such seminal findings as the effects of smoking and high cholesterol on heart disease came from the Framingham Heart Study. At the time of publication these were novel cardiovascular disease (CVD) risk factors, now they are the basis of treatment and prevention in the US. Is the Framingham study now on it's way to becoming the gold standard for genetic epidemiology of CVD? Will the novel genetic findings of today become the health care standards of tomorrow? The accompanying articles summarizing the results of genome-wide association studies (GWAS) give the reader a first glimpse into the possibilities.
弗明汉心脏研究始于1948年，旨在研究波士顿郊外一个小镇的心血管疾病流行病学，现已成为全球心血管流行病学的标准。它是世界上持续时间最长、特征描述最全面的多代研究之一。吸烟和高胆固醇对心脏病的影响等开创性发现就来自弗明汉心脏研究。在发表时，这些都是新的心血管疾病（CVD）风险因素，现在它们是美国治疗和预防的基础。弗明汉研究现在是否正朝着成为CVD遗传流行病学的黄金标准迈进？当今新的基因发现会成为未来的医疗保健标准吗？随附的总结全基因组关联研究（GWAS）结果的文章让读者初步了解了这些可能性。
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