Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227-5301, USA.
Genet Epidemiol. 2009;33 Suppl 1(Suppl 1):S1-7. doi: 10.1002/gepi.20464.
Genetic Analysis Workshop 16 (GAW16) was held on September 17-20, 2008 in St. Louis, Missouri. The focus of GAW16 was on methods and challenges in analysis of single-nucleotide polymorphism data from genome-wide scans. GAW16 attracted 221 participants from 12 countries. The 168 contributions were organized into 17 discussion groups of 6-17 papers each. Three data sets were available for analysis. Two of these were data from ongoing studies, generously provided by the investigators. The North American Rheumatoid Arthritis Consortium provided case-control data on rheumatoid arthritis, and the Framingham Heart Study (FHS) made available information on cardiovascular risk factors for participants in three generations of pedigree data. The third data set included simulated phenotypes for participants in the FHS, using actual pedigree structures and genotypes. This volume includes a paper for each of the 17 discussion groups, summarizing their main findings.
遗传分析研讨会 16 （GAW16）于 2008 年 9 月 17 日至 20 日在密苏里州圣路易斯举行。GAW16 的重点是分析全基因组扫描中单核苷酸多态性数据的方法和挑战。GAW16 吸引了来自 12 个国家的 221 名参与者。168 项贡献被组织成 17 个讨论组，每组 6-17 篇论文。有三个数据集可供分析。其中两个是正在进行的研究的数据，由研究人员慷慨提供。北美类风湿关节炎联合会提供了类风湿关节炎的病例对照数据，弗雷明汉心脏研究（FHS）为三代系谱数据中的参与者提供了心血管危险因素信息。第三个数据集包括 FHS 参与者的模拟表型，使用实际的系谱结构和基因型。本卷包括每个 17 个讨论组的一篇论文，总结了他们的主要发现。
