Dubrey Simon W, Bell Alex, Mittal Tarun K
Department of Cardiology, Hillingdon Hospital, Uxbridge, Middlesex, UK.
Postgrad Med J. 2007 Oct;83(984):618-23. doi: 10.1136/pgmj.2007.060608.
To this day the aetiology of sarcoidosis continues to elude definition. Partially as a consequence of this, little in the way of new therapies has evolved. The enigma of this condition is that, unusually for a disease with the potential for devastating consequences, many patients show spontaneous resolution and recover. Cardiac involvement can affect individuals of any age, gender or race and has a predilection for the conduction system of the heart. Heart involvement can also cause a dilated cardiomyopathy with consequent progressive heart failure. The most common presentation of this systemic disease is with pulmonary infiltration, but many cases will be asymptomatic and are detected on routine chest radiography revealing lymphadenopathy. Current advances lie in the newer methods of imaging and diagnosing this unusual heart disease. This review describes the pathology and diagnosis of this condition and the newer imaging techniques that have developed for determining cardiac involvement.
时至今日,结节病的病因仍难以明确。部分由于这个原因,新疗法进展甚微。这种病症的谜团在于,对于一种可能产生严重后果的疾病而言,许多患者会自发缓解并康复,这颇为罕见。心脏受累可发生于任何年龄、性别或种族的个体,且易累及心脏传导系统。心脏受累还可导致扩张型心肌病,进而引发进行性心力衰竭。这种全身性疾病最常见的表现是肺部浸润,但许多病例并无症状,而是在常规胸部X线检查发现淋巴结病时被检测出来。目前的进展在于用于成像和诊断这种特殊心脏病的新方法。这篇综述描述了这种病症的病理和诊断,以及为确定心脏受累情况而开发的更新的成像技术。