[Ultraviolet irradiation of autologous blood in the complex treatment of patients with diabetes mellitus].

A single reinfusion of UV-irradiated autologous blood was performed in 76 patients with non-insulin-dependent (NID) and insulin-dependent (ID) diabetes mellitus. Lipid peroxidation (LPO), activity of glycolysis and pentose cycle principal enzymes, red cell cyclic nucleotides, hormones concentrations, glucose utilization were investigated. It is shown that general physiological action of UV radiation is primarily due to LPO stimulation responsible for changes in cell membrane properties. This action may vary with baseline LPO characteristics. UV radiation is valid in combined therapy of NID diabetes mellitus as it activates intracellular metabolism, reduces concentration of ++contra-insular hormones, improves tissue utilization of glucose. ID diabetes mellitus is contraindication for UV radiation use as additional stimulation of initially high LPO entails inhibition of activity of intracellular enzymatic systems participating in glucose metabolism, leads to low production of endogenous insulin.